10-KPeriod: FY2010

BIOGEN INC. Annual Report, Year Ended Dec 31, 2010

Filed February 4, 2011For Securities:BIIB

Summary

Biogen Idec's 2010 10-K report highlights a company focused on neurological disorders with a portfolio driven by AVONEX, TYSABRI, and RITUXAN. Total revenues grew by 7.7% to $4.7 billion, primarily fueled by strong performance in AVONEX and TYSABRI, which saw revenue increases of 8.4% and 16.0% respectively. Despite an overall increase in revenue, income from operations saw a slight decrease of 3.6% due to increased restructuring charges, a significant acquired in-process R&D charge, and higher collaboration profit sharing expenses. The company is undergoing a significant strategic shift, announced in late 2010, to focus primarily on neurology and reallocate R&D resources. This includes terminating or out-licensing oncology and cardiovascular programs and reducing workforce by 13%. Several business development activities occurred in 2010, including the acquisition of Panima Pharmaceuticals AG and new collaboration terms for ocrelizumab and GA101 with Genentech, alongside a license agreement for dexpramipexole. Investors should note the ongoing safety monitoring and regulatory discussions for TYSABRI related to PML risks. Looking ahead, Biogen Idec expects continued competition in the Multiple Sclerosis market and is actively managing its product pipeline and operational structure to drive future growth. The company's financial position remains robust with significant cash reserves, and it actively repurchased shares in 2010.

Financial Statements
Beta
Revenue$4.72B
Cost of Revenue$400.26M
Gross Profit$4.32B
R&D Expenses$1.25B
SG&A Expenses$1.03B
Operating Expenses$3.47B
Operating Income$1.25B
Interest Expense$36.10M
Net Income$1.01B
EPS (Basic)$3.98
EPS (Diluted)$3.94
Shares Outstanding (Basic)252.31M
Shares Outstanding (Diluted)254.87M

Key Highlights

  • 1Total revenues increased 7.7% to $4.7 billion in 2010, driven by strong sales of AVONEX (up 8.4%) and TYSABRI (up 16.0%).
  • 2Net income attributable to Biogen Idec Inc. increased 3.6% to $1.0 billion.
  • 3Diluted EPS increased 17.6% to $3.94.
  • 4Company announced a strategic restructuring initiative to focus on neurology, reallocate R&D, and reduce workforce by approximately 13%, with expected annual savings of $300 million.
  • 5Significant investment in R&D continues, with $1.25 billion spent in 2010, including a $205 million charge related to the Knopp acquisition.
  • 6TYSABRI sales growth continues despite significant safety warnings related to PML, with ongoing efforts to stratify patient risk.
  • 7RITUXAN revenues saw a slight decrease of 1.6%, largely due to royalty expirations in rest-of-world markets, although U.S. co-promotion profits increased.
  • 8Acquisition of Panima Pharmaceuticals AG completed in December 2010 for up to $395 million in contingent consideration.

Frequently Asked Questions

Biogen Idec's primary revenue drivers are its marketed products: AVONEX (for multiple sclerosis), TYSABRI (for multiple sclerosis and Crohn's disease), and RITUXAN (for non-Hodgkin's lymphoma, rheumatoid arthritis, and chronic lymphocytic leukemia, marketed in collaboration with Genentech). AVONEX and TYSABRI are particularly significant for the company's revenue.

Biogen Idec announced a strategic shift to focus primarily on neurology, reallocating R&D resources to high-potential programs. This includes discontinuing or out-licensing oncology and cardiovascular programs, reducing its workforce by approximately 13%, and closing facilities to improve efficiency and cost-effectiveness.

The major risks highlighted for TYSABRI revolve around the serious brain infection progressive multifocal leukoencephalopathy (PML). The risk of PML increases with prior immunosuppressant use and longer treatment duration. The company is actively researching ways to mitigate this risk, including developing a JC virus antibody assay, but ongoing regulatory discussions and potential label changes could impact sales growth.

Biogen Idec has global operations and is exposed to foreign currency exchange rate fluctuations. To mitigate this risk, the company uses foreign currency forward contracts to hedge forecasted international revenues and certain balance sheet items. These hedging activities are designed to reduce the volatility of net income and earnings per share.