8-KOther EventsExhibits & Filings

BRISTOL MYERS SQUIBB CO 8-K Report, Corporate Update (Mar 21, 2006)

Filed March 21, 2006For Securities:BMYCELG-RIBMYMP

Summary

This 8-K filing from Bristol-Myers Squibb (BMY) announces a potential settlement agreement with Apotex Inc. and Apotex Corp. regarding the patent infringement lawsuit for clopidogrel bisulfate, marketed as PLAVIX® in the United States. The agreement, reached with co-marketer sanofi-aventis, aims to resolve litigation concerning the validity of the composition of matter patent for PLAVIX®. While a settlement could provide clarity on future competition, it is contingent upon several conditions, including antitrust review and clearance from the Federal Trade Commission and state attorneys general. There is a significant risk that these clearances may not be obtained, which would reinstate the litigation and allow Apotex to potentially launch a generic version of clopidogrel at risk. Investors should closely monitor the antitrust review process and any further developments concerning the PLAVIX® patent and potential generic entry.

Key Highlights

  • 1BMY and sanofi-aventis have reached a conditional settlement agreement with Apotex Inc. and Apotex Corp. to resolve a patent infringement lawsuit related to PLAVIX® (clopidogrel bisulfate).
  • 2The lawsuit concerns the validity of the composition of matter patent for PLAVIX®.
  • 3The trial, originally scheduled for June 2006, has been suspended pending finalization of the proposed settlement.
  • 4The settlement is subject to significant conditions, including antitrust review and clearance by the FTC and state attorneys general.
  • 5There is a substantial risk that antitrust clearance may not be obtained, which would terminate the settlement and reinstate the litigation.
  • 6If litigation is reinstated, Apotex could launch a generic clopidogrel at risk, as they have received FDA approval for their abbreviated new drug application (aNDA).
  • 7The company states it is not possible at this time to reasonably assess the outcome of the lawsuit or the timing of potential generic competition.

Frequently Asked Questions

Bristol-Myers Squibb (BMY), along with its partner sanofi-aventis, has announced a conditional agreement to settle a patent infringement lawsuit with Apotex Inc. and Apotex Corp. concerning PLAVIX® (clopidogrel bisulfate).

The primary risk is the failure to obtain necessary antitrust clearance from the Federal Trade Commission and state attorneys general. If this clearance is not granted, the settlement will be terminated, and the patent litigation will be reinstated.

If the settlement fails and litigation is reinstated, Apotex could launch a generic version of clopidogrel at risk, potentially leading to significant competition and a decline in PLAVIX® sales. Apotex has already received FDA approval for its generic version.

The filing states that it is not possible at this time to reasonably assess the outcome of the lawsuit or the timing of potential generic competition. The timeline will depend on the antitrust review process and the potential reinstatement of litigation.